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Rust, Michael J.

One or more keywords matched the following properties of Rust, Michael J.

Property	Value
keywords	Circadian Rhythms
overview	Bacteria are an ancient form of life that occupies almost every conceivable niche, from pathogenesis to commensal existence with an animal host to primary production in oceans and lake. Despite their apparent simplicity, bacteria possess sophisticated biochemical networks that dynamically store information about the size and status of the cell and conditions in the external environment. These biochemical systems allow precise decision making that allow microbes to thrive in challenging conditions. Our lab is interested in the design principles of these reaction networks. We use a multidisciplinary approach: biochemical reconstitution of the underlying interactions, single cell microscopy to study function, and mathematical modeling to rebuild systems in silico. A major focus area is bacterial circadian rhythms, which allow single cells to predict the time of day.

Property

Value

keywords

Circadian Rhythms

overview

Bacteria are an ancient form of life that occupies almost every conceivable niche, from pathogenesis to commensal existence with an animal host to primary production in oceans and lake. Despite their apparent simplicity, bacteria possess sophisticated biochemical networks that dynamically store information about the size and status of the cell and conditions in the external environment. These biochemical systems allow precise decision making that allow microbes to thrive in challenging conditions. Our lab is interested in the design principles of these reaction networks. We use a multidisciplinary approach: biochemical reconstitution of the underlying interactions, single cell microscopy to study function, and mathematical modeling to rebuild systems in silico. A major focus area is bacterial circadian rhythms, which allow single cells to predict the time of day.

One or more keywords matched the following items that are connected to Rust, Michael J.

Item Type	Name
Concept	Circadian Rhythm
Concept	Circadian Rhythm Signaling Peptides and Proteins
Academic Article	Orderly wheels of the cyanobacterial clock.
Academic Article	Light-driven changes in energy metabolism directly entrain the cyanobacterial circadian oscillator.
Academic Article	Ordered phosphorylation governs oscillation of a three-protein circadian clock.
Academic Article	Robust and tunable circadian rhythms from differentially sensitive catalytic domains.
Academic Article	Mixtures of opposing phosphorylations within hexamers precisely time feedback in the cyanobacterial circadian clock.
Academic Article	The cyanobacterial clock and metabolism.
Academic Article	Rhythms in energy storage control the ability of the cyanobacterial circadian clock to reset.
Academic Article	Circadian rhythms. A protein fold switch joins the circadian oscillator to clock output in cyanobacteria.
Academic Article	Geographically Resolved Rhythms in Twitter Use Reveal Social Pressures on Daily Activity Patterns.
Academic Article	Molecular dynamics simulations of nucleotide release from the circadian clock protein KaiC reveal atomic-resolution functional insights.
Academic Article	Biophysical clocks face a trade-off between internal and external noise resistance.
Academic Article	Kalman-like Self-Tuned Sensitivity in Biophysical Sensing.
Academic Article	The circadian clock ensures successful DNA replication in cyanobacteria.
Academic Article	Biological rhythms: The suspended animation clock.
Academic Article	KidA, a multi-PAS domain protein, tunes the period of the cyanobacterial circadian oscillator.

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Circadian Rhythm